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KMID : 0364219720150030095
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Korean Journal of Zoology
1972 Volume.15 No. 3 p.95 ~ p.100
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X-ray Induced Unscheduled DNA Synthesis in Relation to Chromosome Exchange and Mitotic Activity in Established Mammalian Cells
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Park Sang-Dai
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Abstract
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Dose response and time dependence of unscheduled DNA synthesis induced by X-rays were measured to determine if any correlation exists between unscheduled DNA synthesis, modal chromosome number, chromosome exchange and mitotic activity in four mammalian cell strains. Unscheduled DNA synthesis occurred in all strains studied. The rate was dose-dependent and strain-specific. Only HeLa $S_3$ showed a staturated dose response after 4, 000 R, other cells were linearly proportional to dose increases. Time dependence of unscheduled DNA synthesis was completed within 2 hours after irradiation regardless of cell strains. Unscheduled DNA synthesis was not directly related to modal chromosome number, total exchange rate and mitotic activity. Mitotic activity and chromosome exchange were both dose-dependent, but the rates of them were inversely related.
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